Title | Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Wang, H, Burnett, T, Kono, S, Haiman, CA, Iwasaki, M, Wilkens, LR, Loo, LWM, Van Den Berg, D, Kolonel, LN, Henderson, BE, Keku, TO, Sandler, RS, Signorello, LB, Blot, WJ, Newcomb, PA, Pande, M, Amos, CI, West, DW, Bézieau, S, Berndt, SI, Zanke, BW, Hsu, L, Lindor, NM, Haile, RW, Hopper, JL, Jenkins, MA, Gallinger, S, Casey, G, Stenzel, SL, Schumacher, FR, Peters, U, Gruber, SB, Tsugane, S, Stram, DO, Le Marchand, L |
Corporate Authors | , , |
Journal | Nat Commun |
Volume | 5 |
Pagination | 4613 |
Date Published | 2014 |
ISSN | 2041-1723 |
Abstract | The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations. |
DOI | 10.1038/ncomms5613 |
Alternate Journal | Nat Commun |
PubMed ID | 25105248 |
PubMed Central ID | PMC4180879 |
Grant List | 1R01-CA104132 / CA / NCI NIH HHS / United States 1R01-CA126895 / CA / NCI NIH HHS / United States 1R01-CA126895-S1 / CA / NCI NIH HHS / United States 2U24-CA074806 / CA / NCI NIH HHS / United States CA 087969 / CA / NCI NIH HHS / United States CA-95-011 / CA / NCI NIH HHS / United States CA16672 / CA / NCI NIH HHS / United States HHSN268201100001C / / PHS HHS / United States HHSN268201100002C / / PHS HHS / United States HHSN268201100003C / / PHS HHS / United States HHSN268201100004C / / PHS HHS / United States HHSN268201100046C / / PHS HHS / United States HHSN271201100004C / / PHS HHS / United States K05 CA154337 / CA / NCI NIH HHS / United States K05 CA154337 / CA / NCI NIH HHS / United States K07 CA160753 / CA / NCI NIH HHS / United States K07CA160753 / CA / NCI NIH HHS / United States P01 CA 055075 / CA / NCI NIH HHS / United States P01 CA 087969 / CA / NCI NIH HHS / United States P01 CA033619 / CA / NCI NIH HHS / United States P01 CA033619 / CA / NCI NIH HHS / United States P01 CA055075 / CA / NCI NIH HHS / United States P01 CA087969 / CA / NCI NIH HHS / United States P30 CA014089 / CA / NCI NIH HHS / United States P30 CA014089 / CA / NCI NIH HHS / United States P30 CA016672 / CA / NCI NIH HHS / United States P50 CA 106991 / CA / NCI NIH HHS / United States P50 CA 127003 / CA / NCI NIH HHS / United States P50 CA106991 / CA / NCI NIH HHS / United States P50 CA127003 / CA / NCI NIH HHS / United States R01 137178 / / PHS HHS / United States R01 CA 66635 / CA / NCI NIH HHS / United States R01 CA042182 / CA / NCI NIH HHS / United States R01 CA042182 / CA / NCI NIH HHS / United States R01 CA048998 / CA / NCI NIH HHS / United States R01 CA059045 / CA / NCI NIH HHS / United States R01 CA059045 / CA / NCI NIH HHS / United States R01 CA063464 / CA / NCI NIH HHS / United States R01 CA066635 / CA / NCI NIH HHS / United States R01 CA076366 / CA / NCI NIH HHS / United States R01 CA076366 / CA / NCI NIH HHS / United States R01 CA081488 / CA / NCI NIH HHS / United States R01 CA092447 / CA / NCI NIH HHS / United States R01 CA104132 / CA / NCI NIH HHS / United States R01 CA126895 / CA / NCI NIH HHS / United States R01 CA132839 / CA / NCI NIH HHS / United States R01 CA137178 / CA / NCI NIH HHS / United States R01 CA137178 / CA / NCI NIH HHS / United States R01 CA48998 / CA / NCI NIH HHS / United States R01 CA60987 / CA / NCI NIH HHS / United States R01 CA63464 / CA / NCI NIH HHS / United States R01 CA81488 / CA / NCI NIH HHS / United States R01-CA1326792 / CA / NCI NIH HHS / United States R01-CA132839 / CA / NCI NIH HHS / United States R01CA092447 / CA / NCI NIH HHS / United States R37 CA054281 / CA / NCI NIH HHS / United States R37 CA54281 / CA / NCI NIH HHS / United States RC2 CA148085 / CA / NCI NIH HHS / United States RC2-CA148085 / CA / NCI NIH HHS / United States T32 ES013678 / ES / NIEHS NIH HHS / United States T32 ES013678 / ES / NIEHS NIH HHS / United States T32 HG000040 / HG / NHGRI NIH HHS / United States T32 HG000040 / HG / NHGRI NIH HHS / United States U01 CA 093326 / CA / NCI NIH HHS / United States U01 CA074783 / CA / NCI NIH HHS / United States U01 CA074783 / CA / NCI NIH HHS / United States U01 CA074794 / CA / NCI NIH HHS / United States U01 CA074794 / CA / NCI NIH HHS / United States U01 CA074799 / CA / NCI NIH HHS / United States U01 CA074799 / CA / NCI NIH HHS / United States U01 CA074800 / CA / NCI NIH HHS / United States U01 CA074800 / CA / NCI NIH HHS / United States U01 CA074806 / CA / NCI NIH HHS / United States U01 CA093326 / CA / NCI NIH HHS / United States U01 CA097735 / CA / NCI NIH HHS / United States U01 CA097735 / CA / NCI NIH HHS / United States U01 CA122839 / CA / NCI NIH HHS / United States U01 CA137088 / CA / NCI NIH HHS / United States U01 CA137088 / CA / NCI NIH HHS / United States U01 HG 004438 / HG / NHGRI NIH HHS / United States U01 HG004446 / HG / NHGRI NIH HHS / United States U01 HG004446 / HG / NHGRI NIH HHS / United States U01 HG004726 / HG / NHGRI NIH HHS / United States U01-HG004726 / HG / NHGRI NIH HHS / United States U01CA122839 / CA / NCI NIH HHS / United States U19 CA148107 / CA / NCI NIH HHS / United States U19 CA148107 / CA / NCI NIH HHS / United States U24 CA074806 / CA / NCI NIH HHS / United States UM1 CA167552 / CA / NCI NIH HHS / United States UM1 CA167552 / CA / NCI NIH HHS / United States Z01 CP 010200 / CP / NCI NIH HHS / United States / / Canadian Institutes of Health Research / Canada |
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592. The content is solely the responsibility
of the authors and does not necessarily represent the official views of the
National Institutes of Health.
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592 by the use of the following Cancer Center
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