Title | Elafin is a biomarker of graft-versus-host disease of the skin. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Paczesny, S, Braun, TM, Levine, JE, Hogan, J, Crawford, J, Coffing, B, Olsen, S, Choi, SW, Wang, H, Faca, V, Pitteri, S, Zhang, Q, Chin, A, Kitko, C, Mineishi, S, Yanik, G, Peres, E, Hanauer, DA, Wang, Y, Reddy, P, Hanash, S, Ferrara, JLM |
Journal | Sci Transl Med |
Volume | 2 |
Issue | 13 |
Pagination | 13ra2 |
Date Published | 2010 Jan 6 |
ISSN | 1946-6242 |
Keywords | Adolescent, Adult, Aged, Biological Markers, Child, Child, Preschool, Elafin, Enzyme-Linked Immunosorbent Assay, Graft vs Host Disease, Humans, Infant, Infant, Newborn, Middle Aged, Prognosis, Skin |
Abstract | Graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow transplantation, affects the skin, liver, and gastrointestinal tract. There are no plasma biomarkers specific for any acute GVHD target organ. We used a large-scale quantitative proteomic discovery procedure to identify biomarker candidates of skin GVHD and validated the lead candidate, elafin, with enzyme-linked immunosorbent assay in samples from 492 patients. Elafin was overexpressed in GVHD skin biopsies. Plasma concentrations of elafin were significantly higher at the onset of skin GVHD, correlated with the eventual maximum grade of GVHD, and were associated with a greater risk of death relative to other known risk factors (hazard ratio, 1.78). We conclude that elafin has significant diagnostic and prognostic value as a biomarker of skin GVHD. |
DOI | 10.1126/scitranslmed.3000406 |
Alternate Journal | Sci Transl Med |
PubMed ID | 20371463 |
PubMed Central ID | PMC2895410 |
Grant List | P01 CA039542 / CA / NCI NIH HHS / United States P01 CA039542-20 / CA / NCI NIH HHS / United States P01-CA039542-20 / CA / NCI NIH HHS / United States P30 CA046592 / CA / NCI NIH HHS / United States P30 CA046592-19 / CA / NCI NIH HHS / United States P30CA46592 / CA / NCI NIH HHS / United States RC1 HL101102 / HL / NHLBI NIH HHS / United States RC1 HL101102-01 / HL / NHLBI NIH HHS / United States RC1-HL-101102 / HL / NHLBI NIH HHS / United States |
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592. The content is solely the responsibility
of the authors and does not necessarily represent the official views of the
National Institutes of Health.
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592 by the use of the following Cancer Center
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