Title | Obesity and angiolymphatic invasion in primary breast cancer. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Gillespie, EF, Sorbero, ME, Hanauer, DA, Sabel, MS, Herrmann, EJ, Weiser, LJ, Jagielski, CH, Griggs, JJ |
Journal | Ann Surg Oncol |
Volume | 17 |
Issue | 3 |
Pagination | 752-9 |
Date Published | 2010 Mar |
ISSN | 1534-4681 |
Keywords | Adult, Body Mass Index, Breast Neoplasms, Diabetes Mellitus, Female, Hormone Replacement Therapy, Humans, Hypertension, Lymphatic Metastasis, Menopause, Middle Aged, Neoplasm Staging, Obesity, Receptor, ErbB-2, Receptors, Estrogen, Receptors, Progesterone, Survival Rate, Treatment Outcome, Vascular Neoplasms, Young Adult |
Abstract | BACKGROUND: Obesity is associated with poorer breast cancer-specific survival. The purpose of this study was to investigate the relationships between obesity and the presence of angiolymphatic invasion as well as other features of invasive breast cancer, including stage at presentation, estrogen receptor (ER) status, triple-negative phenotype, and tumor grade.METHODS: Detailed clinical and pathologic data were abstracted from the medical records of all 1,312 patients with stage I-III primary breast cancer who had breast surgery at the University of Michigan Comprehensive Cancer Center between January 1, 2000 and December 31, 2006. Bivariate and multivariate analyses were conducted to investigate the relationships between body mass index and tumor biologic features, controlling for menopausal status, diabetes and hypertension, hormone replacement therapy before diagnosis, race, and ethnicity.RESULTS: In multivariate analyses, severe obesity was independently associated with the presence of angiolymphatic invasion [odds ratio (OR) 1.80, 95% confidence interval (CI) 1.08-2.99, joint test of significance, P = 0.03]. Severe obesity was associated with lower likelihood of triple-negative breast cancer (OR 0.39, 95% CI 0.16-0.96). Among premenopausal women with diabetes, ER-negative (OR 5.22, 95% CI 1.12-24.29) and triple-negative (OR 14.8, 95% CI 1.92-113.91) disease was significantly more common.DISCUSSION: In this large sample of invasive breast cancers, obesity was independently associated with the presence of angiolymphatic invasion. Higher rates of angiolymphatic invasion among obese women may account in part for poorer outcomes among obese women with breast cancer. |
DOI | 10.1245/s10434-009-0797-6 |
Alternate Journal | Ann. Surg. Oncol. |
PubMed ID | 19898898 |
Grant List | R01 CA092444 / CA / NCI NIH HHS / United States R01 CA922444-01 / CA / NCI NIH HHS / United States |
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592. The content is solely the responsibility
of the authors and does not necessarily represent the official views of the
National Institutes of Health.
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592 by the use of the following Cancer Center
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